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目的：探讨心钠素治疗妊高征的临床效果及机理。方法：心钠素治疗妊高征病人６０例，硫酸镁治疗妊高征病人３０例。观察治疗前后血压、尿蛋白、血心钠素、超氧化物歧化酶、肾素、血管紧张素、醛固酮的变化。结果：病人经心钠素治疗后，血压明显下降，尿蛋白转阴，水肿消退，血中超氧化物歧化酶、肾素、血管紧张素、醛固酮减少。结论：心钠素可有效地纠正妊高征病人的病理生理变化，达到降压、利尿、消除尿蛋白的效果。近期、远期未发现对母婴有不良影响。
Objective: To investigate the clinical effect and mechanism of atrial natriuretic peptide in the treatment of pregnancy induced hypertension. Methods: Sixty cases of atrial fibrillation (PIH) were treated with atrial natriuretic peptide and 30 cases were treated with magnesium sulfate. The changes of blood pressure, urinary protein, blood atrial natriuretic peptide, superoxide dismutase, renin, angiotensin and aldosterone were observed before and after treatment. Results: After treatment with atrial natriuretic peptide, blood pressure decreased significantly, urinary protein turned negative, edema subsided, blood superoxide dismutase, renin, angiotensin and aldosterone decreased. Conclusion: Atrial natriuretic peptide can effectively correct pathophysiological changes in patients with PIH and achieve the effects of lowering blood pressure, diuresis and elimination of urinary protein. Recently, no adverse effects on mothers and fat have not been found in the long run.