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分子结构与其保留值规律是色谱热力学研究的主要内容。鉴于此,不少色谱工作者为探求分子结构与色谱保留值之间的关系作了不懈努力。James和Martin首先注意到在气-液色谱中脂肪酸类物质保留体积的对数与溶质分子中的碳原子数存在着近似的线性关系,因而可以据此推测同系物的保留体积。Ray、Littlewood等人随后指出对于烷烃醇、酯以及甲基酮类化合物在多种固定相上也有类似的关系存在,故Ray建议采用保留体积的对数对分子的键长作图,并以此来鉴别未知物。因
The molecular structure and the law of its retention are the main contents of chromatographic thermodynamics. In view of this, many chromatographers have made unremitting efforts to explore the relationship between molecular structure and chromatographic retention. James and Martin first noticed that there was an approximate linear relationship between the logarithm of the retention volume of fatty acids and the number of carbon atoms in the solute molecule in a gas-liquid chromatogram, and thus the retention volume of the homologue could be deduced. Ray, Littlewood et al. Then pointed out that Alkane alcohols, esters, and methyl ketones also have similar relationships across multiple stationary phases, so Ray recommends using the logarithm of the retention volume to map the bond lengths of the molecules To identify unknowns. because