【摘 要】
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Chemical genomics has been applied extensively to evaluate small molecules that modulate biological processes in Saccharomyces cerevisiae.Here,we use yeast as a
【机 构】
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The National Center for Drug Screening and the CAS Key Laboratory of Receptor Research,Shanghai Inst
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Chemical genomics has been applied extensively to evaluate small molecules that modulate biological processes in Saccharomyces cerevisiae.Here,we use yeast as a surrogate system for studying compounds that are active against metazoan targets.Large-scale chemical-genetic profiling of thousands of synthetic and natural compounds from the Chinese National Compound Library identified those with high-confidence bioprocess target predictions.To discover compounds that have the potential to function like therapeutic agents with known targets,we also analyzed a reference library of approved drugs.Previously uncharacterized compounds with chemical-genetic profiles resembling existing drugs that modulate autophagy and Wnt/β-catenin signal transduction were further examined in mammalian cells,and new modulators with specific modes of action were validated.This analysis exploits yeast as a general platform for predicting compound bioactivity in mammalian cells.
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