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目的探讨冠状动脉慢血流99m Tc MIBI心肌血流灌注断层显像异常与冠脉内局部内皮素-1(ET-1)和一氧化氮(NO)浓度相关性分析。方法将2013年8月~2015年2月在某医院心内科冠状动脉慢血流98例患者,同期行SPECT检查。42例慢血流合并心肌灌注分布异常者作为慢血流核素分布异常组,其余56例为对照组。描述两组临床特征、冠心病危险因素及实验室检查指标。结果与对照组比较,慢血流合并核素分布异常组ET-1水平显著增高(P<0.05),而血清NO水平显著降低(P<0.05)。Logistic回归分析显示慢血流核素分布异常吸烟者高于非吸烟者(β=1.212,OR=4.564,P<0.05)。结论冠脉局部ET-1升高,NO降低可能诱发慢血流心肌血流灌注断层显像异常,吸烟可能加重这种现象。
Objective To investigate the correlation between 99m Tc MIBI myocardial perfusion imaging and coronary endothelin-1 (ET-1) and nitric oxide (NO) concentrations in coronary artery. Methods From August 2013 to February 2015, 98 patients with coronary artery slow blood flow in the cardiology department of a hospital were examined by SPECT at the same period. Forty-two patients with abnormal distribution of slow blood flow and myocardial perfusion were used as the abnormal distribution of slow blood flow radionuclide, and the remaining 56 cases as the control group. Describe the clinical characteristics of two groups, risk factors for coronary heart disease and laboratory tests. Results Compared with the control group, ET-1 level was significantly increased in patients with abnormal blood flow and radionuclide distribution (P <0.05), while serum NO level was significantly decreased (P <0.05). Logistic regression analysis showed that the distribution of abnormal blood flow in nude smokers was higher than that in nonsmokers (β = 1.212, OR = 4.564, P <0.05). Conclusions Coronary ET-1 increased and NO decreased, which may induce abnormal perfusion imaging of myocardial perfusion in slow blood flow. Smoking may aggravate this phenomenon.