论文部分内容阅读
目的了解新型肝炎病毒TFV与乙型肝炎病毒（HBV）混合感染对肝脏病变及HBV复制状态的影响。方法套式聚合酶链反应检测乙型肝炎患者血清TTVDNA并对检测结果和临床资料进行统计学分析。结果177例慢性HBV感染者中32例TTVDNA阳性，阳性率18．1％：其中无症状携带者5/52（9．6％），慢性肝炎7/46（15.2％），重型肝炎9/39（23．1％），活动性肝硬化9／40（22．5％），各组间无统计学差异；在慢性肝炎、重型肝炎及活动性肝硬化病人中，TTV阳性者与TTV阴性者的各项肝功能指标及血清HBeAg阳性率无统计学差异；但HBV、TTV混合感染的重型肝炎死亡率较高，具有统计学意义。，结论TTV混合感染似乎不影响HBV所致的肝脏病变及其复制状态，但可能影响重型肝炎的预后。
Objective To investigate the effect of novel hepatitis B virus (TFV) and hepatitis B virus (HBV) mixed infection on the pathological changes of liver and HBV replication. Methods The detection of serum TTVDNA in patients with hepatitis B by nested polymerase chain reaction and the detection results and clinical data were statistically analyzed. Results Of the 177 patients with chronic HBV infection, 32 cases were positive for TTVDNA, with a positive rate of 18.1%: 5/52 (9.6%) of asymptomatic carriers, 7/46 (15.2%) of chronic hepatitis and 9/39 (23.1%), and active cirrhosis 9/40 (22.5%). There was no significant difference among the groups. Among patients with chronic hepatitis, severe hepatitis and active cirrhosis, TTV-positive patients and TTV-negative patients Of the liver function and serum HBeAg positive rate was no significant difference; but HBV, TTV mixed infection of severe hepatitis mortality was higher, with statistical significance. Conclusions TTV mixed infection does not seem to affect HBV-induced liver lesions and their replication status, but may affect the prognosis of severe hepatitis.