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The age at diagnosis of 242 girls with Turner syndrome (TS)-treated in Belgium with growth hormone between 1991 and 2002 was evaluated.The median (range) age at diagnosis was 6.6 (0-18.3) years.Patients with 45,X karyotype were diagnosed earlier than patients with other karyotypes.Compared to a previous survey, performed on 100 patients 12 years earlier, more patients were diagnosed during infancy and childhood, and less during adolescence.However, in 22%of the girls the diagnosis was made after the age of 12 years; these girls showed the largest height deficit.As early diagnosis has several potential advantages we recommend that a cytogenetic analysis should be considered in all girls with unexplained short stature with height below-2 SD of the mean for age or below the parent specific lower limit of height.
The age at diagnosis of 242 girls with Turner syndrome (TS) -treated in Belgium with growth hormone between 1991 and 2002 was was. The median (range) age at diagnosis was 6.6 (0-18.3) years. Patients with 45, X karyotype were diagnosed earlier than patients with other karyotypes .Compared to a previous survey, performed on 100 patients 12 years earlier, more patients were diagnosed during infancy and childhood, and less during adolescence. Host, in 22% of the girls the diagnosis was made after the age of 12 years; these girls showed the largest height deficit. As early as has several potential advantages we recommend that a cytogenetic analysis should be considered in all girls with unexplained short stature with height below-2 SD of the mean for age or below the parent specific lower limit of height