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目的:观察新诊断的2型糖尿病患者早期应用胰岛素强化治疗的疗效。方法:对新诊断的2型糖尿病患者89例,行糖尿病知识宣教,给予饮食及运动指导,应用胰岛素强化治疗。血糖达标后3个月观察BMI、胰岛素用量、糖化血红蛋白、胰功、血脂及心电图情况。结果:血糖达标时间2~10 d,3个月后胰岛素用量与血糖达标时比较明显减少,治疗前后比较血脂、心电图异常改善,BMI、糖化血红蛋白、胰岛素抵抗指数下降,无严重低血糖事件。结论:新诊断的2型糖尿病患者早期应用胰岛素强化治疗能迅速控制高血糖,去除糖毒性和脂毒性,保护B细胞功能,减轻胰岛素抵抗,是安全有效的基本治疗措施。
Objective: To observe the effect of early intensive insulin therapy on newly diagnosed type 2 diabetic patients. Methods: Eighty-nine newly diagnosed type 2 diabetic patients underwent diabetes education, diet and exercise instruction, and intensive insulin therapy. Three months after reaching the blood glucose level, BMI, insulin dosage, glycosylated hemoglobin, pancreatic function, blood lipid and electrocardiogram were observed. Results: The blood glucose reached the standard of 2 to 10 days. After 3 months, the amount of insulin decreased significantly compared with the standard of blood glucose. Before and after treatment, the blood lipid was improved. The abnormal ECG, BMI, glycosylated hemoglobin and insulin resistance index decreased without severe hypoglycemia. Conclusion: The newly diagnosed type 2 diabetic patients with early intensive insulin therapy can quickly control hyperglycemia, remove sugar toxicity and lipotoxicity, protect B cell function and reduce insulin resistance, which is a safe and effective basic treatment.