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目的了解广东中山市体检人群高尿酸血症(HUA)的患病情况及其与血清肌酐和血糖的关系。方法收集2012~2014年在中山市人民医院健康体检中检出的16 680例HUA患者资料,对其血清尿酸、血清肌酐、空腹血糖水平进行分析。结果 16 680例HUA患者中,男女比例为7∶1。男性HUA患者平均年龄低于女性HUA患者,其血清尿酸水平高于女性患者(P均<0.01)。男、女性HUA患者高血糖者比例比较差异无统计学意义(P>0.05),男性HUA患者血清肌酐异常者比例高于女性患者(P<0.01)。排除年龄、性别因素影响后,HUA患者血清尿酸水平与血糖、血清肌酐呈正相关(r分别为0.47、0.43,P均<0.001)。男性血清尿酸≥488μmol/L组及女性血清尿酸≥467μmol/L组高血糖、血清肌酐异常者比例分别高于男性血清尿酸<488μmol/L组及女性血清尿酸<467μmol/L组(P均<0.05)。结论广东中山市HUA人群中,男性患者居多,HUA合并高血糖、血清肌酐异常的比例高。HUA应值得重视并早期诊治,预防合并症的发生。
Objective To investigate the prevalence of hyperuricemia (HUA) and its association with serum creatinine and blood glucose in Zhongshan City, Guangdong Province. Methods The data of 16 680 cases of HUA detected in Zhongshan People ’s Hospital from 2012 to 2014 were collected and their serum uric acid, serum creatinine and fasting blood glucose levels were analyzed. Results Among 16 680 HUA patients, the male-female ratio was 7: 1. The average age of male HUA patients was lower than that of female HUA patients, the serum uric acid level was higher than female patients (all P <0.01). There was no significant difference in the proportion of hyperglycemia between male and female HUA patients (P> 0.05). The prevalence of serum creatinine in male HUA patients was higher than that in female patients (P <0.01). Excluding the influence of age and sex, the serum uric acid level in HUA patients was positively correlated with blood glucose and serum creatinine (r = 0.47,0.43, P <0.001, respectively). The serum levels of serum uric acid and serum creatinine were higher in male patients with serum uric acid≥488μmol / L and in female patients with serum uric acid≥467μmol / L than those with serum uric acid <488μmol / L and female patients with uric acid <467μmol / L ). Conclusions Among the HUA population in Zhongshan City, Guangdong Province, the majority of male patients have HUA with high proportion of hyperglycemia and abnormal serum creatinine. HUA should be valued and early diagnosis and treatment, prevention of comorbidities.