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杀灭疟原虫有二个途径,一是使用抗疟药物直接作用于疟原虫,二是通过共价修饰血红蛋白使得红细胞不适应疟原虫寄生来达到杀灭疟原虫的目的。由于血红蛋白在寄生虫代谢中是氨基酸的主要来源,而一些药物能共价修饰血红蛋白的,则可阻碍疟原虫蛋白水解酶的消化,使疟原虫的生长受到抑制。但是,这种经修饰后的血红蛋白并没有改变细胞中O_2的运输、交换和其他的正常功能。作者采用不同浓度的阿司匹林及其衍生物:如acetaminophen ibupcofrn、indome-
Malaria parasite kill there are two ways, one is the use of antimalarial drugs directly on the malaria parasite, and the other is covalent modification of hemoglobin so that red blood cells do not adapt to parasitic parasites Malaria parasite to achieve the purpose. Since hemoglobin is a major source of amino acids in parasite metabolism, some drugs covalently modify hemoglobin, which can hinder the digestion of the parasite proteolytic enzyme and inhibit the growth of the parasite. However, this modified hemoglobin did not alter O 2 transport, exchange, and other normal functions in cells. The authors used different concentrations of aspirin and its derivatives: such as acetaminophen ibupcofrn, indome-