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本文研究安定在水杨酸钠溶液中的增溶效果。将过量的安定加到不同浓度(0～30%)水杨酸钠溶液中,于37°±1°下振摇24小时,并放置24小时,分取滤液用0.1NHCl适当稀释,于365nm处测定安定含量。结果加入30%水杨酸钠中,安定的溶解度从8mg%增加到1718mg%。作者认为这是属于增溶的原理。安定的溶解速率实验,是将40mg安定加到37°±1°的400ml水中或不同浓度的水杨酸钠溶液中,然后以60rpm机械搅拌,在不同间隔时间内取样测定。实验表。明,安定的溶解速率随水杨酸钠的浓度增加而提高,认为这是水杨酸钠降低表面张力所致。
This article studies the stability of diazepam in salicylic acid solution solubilization effect. Excess diazepam was added to sodium salicylate solutions of different concentrations (0-30%), shaken at 37 ° ± 1 ° for 24 hours, and left for 24 hours. The filtrate was partitioned and diluted appropriately with 0.1N HCl at 365 nm Determination of stability content. As a result, the stability of diazepam was increased from 8 mg% to 1718 mg% in 30% sodium salicylate. The author believes that this is the principle of solubilization. A stable dissolution rate experiment was performed by adding 40 mg of diazepam to 400 ml of water at 37 ° ± 1 ° or different concentrations of sodium salicylate solution and then mechanically stirring at 60 rpm for sampling at various intervals. Experimental table. Ming, stability and dissolution rate increased with the concentration of sodium salicylate increased, that this is caused by sodium salicylate to reduce the surface tension.