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目的探讨胺碘酮联合倍他乐克治疗快速心律失常的疗效及安全性。方法选取2014年9月—2016年5月河南省第六建筑工程公司职工医院收治的96例快速心律失常患者作为研究对象,采取随机数字表法分为观察组和对照组,每组48例。两组患者均给予常规治疗,对照组于此基础上给予胺碘酮治疗,观察组在对照组治疗基础上联合给予倍他乐克治疗,两组疗程均为8周,疗程结束后对比两组临床疗效及不良反应发生情况。结果观察组总有效率为95.83%,明显高于对照组的70.84%(P<0.01);观察组治疗72 h后心率、收缩压、舒张压均显著低于对照组(P<0.01);观察组不良反应发生率为4.16%,对照组为2.08%,两组不良反应发生率比较差异无统计学意义(P>0.05)。结论胺碘酮联合倍他乐克治疗快速心律失常疗效显著,且不良反应发生率低,安全性高。
Objective To investigate the efficacy and safety of amiodarone combined with betaloc in the treatment of tachyarrhythmia. Methods Ninety-six patients with tachyarrhythmia admitted to the Sixth Construction Engineering Company Hospital of Henan Province from September 2014 to May 2016 were selected as subjects and divided into observation group and control group with 48 cases in each group. Both groups were given routine treatment, the control group on the basis of this amiodarone treatment, the observation group in the control group based on the combination of metoprolol treatment, the two courses of treatment were 8 weeks after the end of the treatment compared with the two groups Clinical efficacy and adverse reactions occurred. Results The total effective rate in the observation group was 95.83%, which was significantly higher than that in the control group (70.84%, P <0.01). The heart rate, systolic pressure and diastolic blood pressure in the observation group were significantly lower than those in the control group after 72 hours of treatment (P <0.01) The incidence of adverse reactions was 4.16% in the control group and 2.08% in the control group. There was no significant difference in the incidence of adverse reactions between the two groups (P> 0.05). Conclusion Amiodarone combined with metoprolol has a significant therapeutic effect on tachyarrhythmia, with low incidence of adverse reactions and high safety.