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目的研究脑栓通颗粒对实验性脑缺血的保护作用。方法采用小鼠断头后张口喘气的方法,观察脑栓通颗粒对小鼠耐缺氧的影响;常压耐缺氧法考察脑栓通颗粒的抗缺氧作用;采用尾静脉注射伊文思蓝溶液,测定脑内的伊文思蓝含量,观察脑栓通颗粒对小鼠血脑通透性的影响;采用结扎大鼠双侧颈总动脉的方法,考察脑栓通颗粒对大鼠脑缺血再灌注损伤的影响。结果脑栓通颗粒能明显延长小鼠断头后喘气时间,对延长小鼠常压耐缺氧下存活时间的效果不明显;脑栓通颗粒中剂量组和高剂量组能明显增加小鼠脑内的伊文思蓝含量,增强血脑通透性;脑栓通颗粒能明显减轻缺血再灌注后大鼠的脑组织含水量,改善水肿状态。结论脑栓通颗粒对实验性脑缺血有保护作用。
Objective To study the protective effect of Naoshitong granule on experimental cerebral ischemia. Methods After the mice were decapitated, their mouths were gasped, and the effect of Naoshitong granule on hypoxia tolerance was observed. The anti-hypoxia effect of Naoxintong granule was observed by the anaerobic hypoxia method. Solution, brain Evans blue content was measured to observe the effect of Naoshuantong particles on blood brain permeability in mice; using bilateral ligation of common carotid artery in rats, to observe the effect of Naoshuantong on cerebral ischemia in rats Effect of reperfusion injury. Results Naoshitong granule can obviously prolong the time of post-decapitation puffing, and has no obvious effect on prolonging the survival time under hypoxia in normal pressure mice. The effect of Naoshitong Granule medium dose group and high dose group can obviously increase the expression of mouse brain Within the Evans blue content, enhance blood brain permeability; brain Shituong particles can significantly reduce the water content of rat brain tissue after ischemia-reperfusion, improve edema state. Conclusion Naoshitong Granule has protective effect on experimental cerebral ischemia.