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目的探讨大肠恶性肿瘤不同术式的效果及对免疫功能的影响。方法选取收治的144例大肠恶性肿瘤患者,以数字表法随机分为观察组和对照组,每组72例。观察组患者行腹腔镜大肠癌根治手术,对照组患者行传统的开腹大肠癌根治手术。对比两组患者的手术时间、术中出血量、住院时间和术后并发症等,术前、术后3 d检测两组患者血清Ig A、Ig G、Ig M和C反应蛋白(CRP)水平。结果观察组患者的手术时间为(183.9±27.4)min,术中出血量为(196.3±41.5)ml,住院时间为(10.9±3.1)d,均少于对照组(P<0.05),术后排气时间和并发症总数均优于对照组(P<0.05)。两组患者术后3 d血清Ig A、Ig G和Ig M出现了小幅度下降,CRP含量上升,观察组患者Ig A、Ig G、Ig M和CRP水平较对照组变化幅度更小,差异均有统计学意义(均P<0.05)。结论腹腔镜大肠恶性肿瘤手术对患者的创伤小,对机体的免疫功能影响也更小。
Objective To investigate the effect of different surgical procedures on colorectal malignant tumor and its effect on immune function. Methods A total of 144 patients with malignant colorectal cancer who were admitted to our hospital were randomly divided into observation group and control group with digital table method, with 72 cases in each group. The patients in the observation group underwent laparoscopic radical resection of colorectal cancer and the control group underwent traditional open radical resection of colorectal cancer. The serum levels of IgA, IgG, IgM and C-reactive protein (CRP) in the two groups were compared before and 3 days after operation by comparing the operation time, intraoperative blood loss, hospital stay and postoperative complications. . Results The operation time of the observation group was (183.9 ± 27.4) min, the blood loss was (196.3 ± 41.5) ml and the hospitalization time was (10.9 ± 3.1) days, both of which were less than those of the control group (P <0.05) The total exhaust time and complications were better than the control group (P <0.05). Serum Ig A, Ig G and Ig M decreased slightly and CRP levels increased 3 days after operation in both groups. The changes of Ig A, Ig G, Ig M and CRP in the observation group were smaller than those in the control group There was statistical significance (all P <0.05). Conclusion Laparoscopic surgery for malignant colorectal cancer patients with small trauma, the immune function of the body is also smaller.