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目的研究系统性红斑狼疮患者血清中脑源性神经营养因子(BDNF)及白细胞介素21(IL-21)的表达情况,并探讨其临床意义。方法采用酶联免疫吸附试验(ELISA)分别检测28例SLE活动期患者及24例SLE稳定期患者血清中BDNF与IL-21的表达水平并以健康志愿者(21例)作对照,同时将二者表达水平与SLE疾病活动程度进行相关分析。结果 SLE活动期及稳定期患者血清中BDNF及IL-21的表达水平均明显高于正常人(P<0.01),活动期患者的表达高于稳定期患者(P<0.01),以上差异均有统计学意义;BDNF的表达与狼疮活动指数(SLEDAI)无明显相关性(P>0.05),而IL-21的表达则与SLEDAI积分呈显著正相关(P<0.01)。结论 BDNF与IL-21可能在一定程度上参与了SLE的发病机制,IL-21有望成为监测SLE病情活动及临床疗效评价的新指标。
Objective To study the expression of serum brain-derived neurotrophic factor (BDNF) and interleukin-21 (IL-21) in patients with systemic lupus erythematosus (SLE) and to investigate its clinical significance. Methods Serum levels of BDNF and IL-21 in 28 patients with active SLE and 24 patients with stable SLE were measured by enzyme-linked immunosorbent assay (ELISA), and healthy volunteers (21 patients) were used as controls. At the same time, The correlation between the level of expression and the degree of SLE disease activity. Results The serum levels of BDNF and IL-21 in active and stable SLE patients were significantly higher than those in normal controls (P <0.01), and those in stable patients were significantly higher than those in stable patients (P <0.01) There was no significant correlation between BDNF expression and SLEDAI (P> 0.05), while IL-21 expression was positively correlated with SLEDAI score (P <0.01). Conclusion BDNF and IL-21 may be involved in the pathogenesis of SLE to a certain extent. IL-21 is expected to become a new indicator for monitoring the activity of SLE and clinical evaluation.