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敌百虫(metrifonatum)收载于上海市药品标准(1974年,以下简称“沪标”)。世界卫生组织已遴选此药为基本药物。该药在生产上系取甲醇、三氯化磷和三氯乙醛一步合成,反应过程中还有氯化氢和甲基氯产生(见燃化出版编辑室:化工生产流程图解)。故沪标中规定检查酸度和氯化物。由于敌百虫水溶液不稳定。特别是在碱性溶液中分解更快、故含量测定中规定以甲醇作溶剂,在碳酸钠碱性下,使一分子敌百虫定量释出一分子敌敌畏和一分子氯化氢,再加入过量硝酸银溶液,用硫氢酸氨液回滴,测得氯离子含量以定出敌百虫含量。沪标中对酸度和氯化物的检查,规定以水作溶剂,但又
Trichlorfon (metrifonatum) contained in the Shanghai drug standards (1974, hereinafter referred to as “Shanghai superscript ”). WHO has selected this medicine as a basic medicine. The drug in the production line Department of methanol, phosphorus trichloride and trichloroacetaldehyde one-step synthesis, the reaction process as well as the production of hydrogen chloride and methyl chloride (see Combustion Publishing House: Chemical Production Flow diagram). Therefore, the provisions of Shanghai superscript inspect acidity and chloride. Due to trichlorfon aqueous solution is not stable. Especially in alkaline solution decomposition faster, so the content determination of the provisions of methanol as a solvent, under the sodium carbonate, the molecular weight of a trichlorfon molecular release of a molecule of dichlorvos and a molecule of hydrogen chloride, and then add excess silver nitrate Solution, with ammonia sulfate back drop, measured chloride ion content to set the trichlorfon content. Shanghai standard acid and chloride in the inspection, the provisions of water as a solvent, but again