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目的:探讨中耳积液中纤维蛋白原含量与分泌性中耳炎病情迁延的关系。方法:用凝固法对98例成人患者中耳积液中纤维蛋白原进行动态检测。结果:98例患者经鼓膜穿刺治疗后62例未愈,治愈组和迁延组纤维蛋白原检测阳性率分别为30.56%和72.58%,P<0.01;浓度分别为(0.350±0.124)g/L和(0.568±0.206)g/L,P<0.05。迁延组中52例患者第2次穿刺治疗中耳积液中纤维蛋白原浓度为(1.241±0.146)g/L,明显高于第1次[(0.685±0.251)g/L],P<0.01。结论:纤维蛋白原含量与分泌性中耳炎病情迁延密切相关,可能在粘连性中耳炎形成中起重要作用。
Objective: To investigate the relationship between the content of fibrinogen in middle ear effusion and the exacerbation of otitis media. Methods: The coagulation method was used to detect fibrinogen in middle ear effusion of 98 adult patients. Results: The positive rates of fibrinogen in cured group and untreated group were 30.56% and 72.58% (P <0.01), and the positive rates were (0.350 ± 0.124) g / L and (0.568 ± 0.206) g / L, P <0.05. The concentration of fibrinogen in the middle ear effusion of 52 patients in the delayed group was (1.241 ± 0.146) g / L, which was significantly higher than that of the 1st [(0.685 ± 0.251) g / L], P <0.01 . Conclusion: The content of fibrinogen is closely related to the exacerbation of otitis media and may play an important role in the formation of otitis media.