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１０４例重症肌无力（ＭＧ）胸腺的临床病理研究，其中６例分别用细胞角蛋白（ＣＫ）、上皮细胞膜抗原（ＥＭＡ）、癌胚抗原（ＣＥＡ）、全Ｔ细胞标记物（ＵＣＨＴＩ）、Ｔ辅助细胞标记物（Ｔ４）、Ｔ抑制细胞标记物（Ｔ８）、Ｂ细胞标记物（Ｌ２６）、Ｓ－１００蛋白（ｓ－１００）作免疫组化和电镜检查，长期随访７３例。结果：光镜下胞腺淋巴细胞增生伴生发中心形成和分枝状增生的毛细血管为其病理特征；电镜下见淋巴细胞可形成丰富的胞浆突起并互相间呈交指状，毛细血管内皮细胞间有缝隙结构形成；免疫组化提示：ＭＧ胸腺内既有Ｔ细胞（ＵＣＨＴ１，Ｔ４）增生，也有８细胞（Ｌ２６）反应和表达ＣＫ，Ｓ－１００阳性细胞。提出了ＭＧ胸腺切除预后与ＭＧ的临床类型、年龄和病理均有关，其中成年Ⅰ、Ⅱ型，胸腺表现增生且不伴胸腺瘤的患者行胸腺切除有效率为９１．５％，预后良好。
A total of 104 cases of myasthenia gravis were studied clinically and pathologically. Among them, 6 cases were treated with cytokeratin (CK), epithelial cell membrane antigen (EMA), carcinoembryonic antigen (CEA), total T cell marker T-cell marker (T8), B cell marker (L26) and S-100 protein (s-100) were detected by immunohistochemistry and electron microscopy in 73 cases. Results: Under the light microscope, the glandular lymphocyte hyperplasia accompanied with the formation of centriole and the proliferation of capillaries were the pathological features. Under the electron microscope, the lymphocytes could form abundant cytoplasmic processes with interdigitating fingers and capillary endothelium The formation of interstitial cells was observed by immunohistochemistry. Both T cells (UCHT1, T4) proliferated in MG thymus, and also expressed in cytoplasm of 8 cells (L26) and CK, S-100 positive cells. The prognosis of MG thymus resection is related to the clinical type, age and pathology of MG. The effective rate of thymectomy for adults with type Ⅰ and Ⅱ thymic hyperplasia without thymoma is 91.5%, and the prognosis is good.