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目的探讨胃腺癌患者凝血、抗凝指标的变化及其分化程度、转移的关系。方法胃腺癌患者50例,对照组30例。检测凝血酶原时间(PT),活化部分凝血活酶时间(APTT),纤维蛋白原(FIB),抗凝血酶(AT)。结果PT、APTT随病情加重稍有延长但各组间差异无统计学意义(P>0.05);FIB随病情加重而增高,AT随病情加重活性逐渐降低,此两项指标各组间差异均有统计学意义(P<0.05)。结论胃腺癌患者存在明显的凝血、抗凝异常且其变化与病情发展及预后有关。
Objective To investigate the changes of coagulation and anticoagulation indexes and their differentiation and metastasis in patients with gastric adenocarcinoma. Methods 50 cases of gastric adenocarcinoma patients and 30 cases of control group. Prothrombin time (PT), activated partial thromboplastin time (APTT), fibrinogen (FIB) and antithrombin (AT) were measured. Results The PT and APTT slightly increased with the aggravation of illness, but there was no significant difference among the groups (P> 0.05). The FIB increased with the aggravation of disease and the activity of AT gradually decreased with the aggravation of illness. There was significant difference between the two groups Statistical significance (P <0.05). Conclusion There are obvious coagulation and anticoagulation abnormalities in patients with gastric adenocarcinoma and their changes are related to the development of the disease and prognosis.