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采用家兔10％～15％III度烫伤模型,将21只纯种家兔随机分为痂下给药I、II组和静脉给药组。每只兔分三期给药(25mg/kg)。分别采用高效液相色谱法(HPLC)和微生物法(MBPD)对照检测头孢哌酮(CPZ)局部和血中药浓度,并以电子计算机处理药代动力学参数。结果表明:①烫伤后痂下CPZ浓度痂下给药组比静脉给药组明显增高(2681/28mg/L);②烫伤后立即痂下给药组消除相半衰期明显延长;③烫伤后9天的创面静脉给药组痂下未检测出药浓度,而痂下给药组局部药浓度消除相半衰期延长;④烫伤后立即痂下给药血中出现两次具有治疗意义的药峰,可以相当两次静脉给药;⑤痂下给药组在直径13cm的周边区,烫伤早期注药后24h和烫伤后第9天注药后36hCPZ药浓度一直大于最小抑菌浓度(MIC)5～8倍。提示:痂下给药是治疗和预防III度焦痂下感染的有效方法之一。
Twenty-one purebred rabbits were randomly divided into I, II group and IV group by scald injury model of 10% ~ 15% III rabbits. Each rabbit was administered in three phases (25 mg / kg). The concentration of cefoperazone (CPZ) in local and blood serum was determined by HPLC and MBPD respectively. The pharmacokinetic parameters were also processed by computer. The results showed that: (1) the scab subcuticular eschar dosage group was significantly higher than that of the intravenous administration group (2681/28 mg / L) after scald; (2) the elimination half-life of scab group was significantly prolonged immediately after scald; Of the wound venous administration group did not detect the drug concentration in the scab, while the eschar subconjunctival administration group local drug concentration elimination phase half-life prolonged; scald immediately after scald administration of blood appear twice the meaning of the drug peak, which can be quite Twice a week intravenous administration; ⑤ subcutaneous administration group in the diameter of 13cm in the peripheral area, scald 24h after injection and injection on the 9th post-scald medicine 36hCPZ concentration has been greater than the minimum inhibitory concentration (MIC) 5 to 8 times . Tip: Subcutaneous administration is one of the effective ways to treat and prevent grade III eschar.