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目的考察在葡萄糖溶液中,吡柔比星和胰岛素配伍的稳定性。方法观察室温、避光、6h内,吡柔比星-胰岛素-5%葡萄糖配伍液的外观、pH变化,观察配伍液中不溶性微粒的变化(《中国药典》2010年版附录),采用高效液相色谱法考察配伍液中吡柔比星、胰岛素含量的变化。结果配伍液在6h内无浑浊、沉淀、气体产生,颜色、pH、不溶性微粒数等无明显变化,吡柔比星、胰岛素含量无明显变化。结论在实验条件下,吡柔比星、胰岛素在5%的葡萄糖注射液中配伍稳定。
Objective To investigate the stability of pirarubicin and insulin in glucose solution. Methods The appearance and pH of pirarubicin-insulin-5% dextrose compatibility solution were observed at room temperature and in the dark in 6 hours. The changes of insoluble particles in the compatibility solution were observed (Appendix of Chinese Pharmacopoeia 2010) Chromatography to explore the compatibility of pirarubicin, insulin content changes. Results There was no turbidity in the compatibility solution within 6h, no significant changes in the sedimentation, gas generation, color, pH and the number of insoluble particles. The content of pirarubicin and insulin did not change significantly. Conclusion Under the experimental conditions, pirarubicin and insulin were stable in 5% glucose injection.