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Objective: To assesses chromosomal aberrations in the abortus in recurrent miscarriage, in the presence of parental chromosomal aberrations. Design: Retrospective comparative cohort study. Setting: Tertiary referral unit in university hospital. Patient(s): One thousand one hundred eight patients with 3- 16 miscarriages before 20 weeks gestation; 113 patients with and 995 without chromosomal aberrations. Intervention(s): Karyotyping by standard G- banding techniques of both parents, and of 205 abortuses collected at curettage. Main Outcome Measure(s): The incidence of the euploidic and aneuploidic abortuses according to the parental karyotype. Result(s): Two hundred three abortuses were successfully karyotyped. In 164 embryos of patients with no parental chromosomal aberrations, 23.2% (38/164) had chromosome aberrations. Of the 39 abortuses karyotyped in patients with chromosomal aberrations, 17 had normal karyotypes, 8 had balanced translocations, 2 had inversions identical to the parents, and 12 (30.8% ) had abnormal karyotypes. This difference is not statistically significant (odd ratio 1.47, 95% confidence interval 0.63- 3.39). Only 4 of the 39 karyotyped abortuses had an unbalanced translocation. Conclusion(s): Parental karyotyping was not particularly predictive of a subsequent miscarriage as a result of chromosomal aberrations as 43.5% of abortuses were euploidic, and the parental aberration was only passed on to the abortus in 10% of cases.
Objective: To assesses chromosomal aberrations in the abortus in recurrent miscarriage, in the presence of parental chromosomal aberrations. Design: Retrospective comparative cohort study. Setting: Tertiary referral unit in university hospital. Patient (s): One thousand one hundred eight hundred patients with 3 - 16 miscarriages before 20 weeks gestation; 113 patients with and 995 without chromosomal aberrations. Intervention (s): Karyotyping by standard G-banding techniques of both parents, and of 205 abortuses collected at curetage. Main Outcome Measure (s): The incidence of the euploidic and aneuploidy abortuses according to the parental karyotype. Result (s): Two hundred three abortuses were successfully karyotyped. In 164 embryos of patients with no parental chromosomal aberrations, 23.2% (38/164) had chromosome aberrations. Of the 39 abortuses karyotyped in patients with chromosomal aberrations, 17 had normal karyotypes, 8 had balanced translocations, 2 had inversions identical to the pare Only 4 of the 39 karyotyped abortuses had an unbalanced translocation. Conclusion (s): Parental and 12 (30.8%) had abnormal karyotypes. This difference is not significant significant (odd ratio 1.47, 95% confidence interval 0.63- 3.39) karyotyping was not particularly predictive of a subsequent miscarriage as a result of chromosomal aberrations as 43.5% of abortuses were euploidic, and the parental aberration was only passed on to the abortus in 10% of cases.