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目的：讨论持续皮下注射胰岛素(CSII)在胰岛素脱敏治疗临床应用价值。方法对6例胰岛素过敏者采用续皮下注射胰岛素脱敏治疗，以0.05U/h稀释胰岛素溶液为起始基础率，逐步增加输注速度和浓度，在此基础上调整治疗方案为餐前皮下注射胰岛素联合口服降糖药物治疗(OAD)。结果6例均脱敏成功，改为皮下注射后未再出现过敏反应。随访2个月，患者空腹血糖(FPG)、餐后2 h血糖(2hPG)和糖化血红蛋白(HbA1c)均下降(<0.01)。结论持续皮下注射胰岛素和生理性分泌胰岛素相似，可用于胰岛素脱敏治疗。“,”Objective To evaluate the application value and nursing methods of insulin pump in desensitization therapy for intradermal insulin allergy. Methods Six patients allergic to insulin received desensitization therapy by continuous subcutaneous insulin infusion. The diluted insulin was pumped in initial basal rate of 0.05U/h, and the infusion speed and insulin concentration were increased gradually to the clinically required insulin dosage. After that the continuous subcutaneous insulin infusion was replaced by regimen of insulin subcutaneous injection plus oral ant-diabetes drugs (OAD). Results All of the 6 cases were successfully desensitized. They did not have the allergic symptoms again after changing to regimen of insulin subcutaneous injection plus OAD. During the follow-up for 2 months, their levels of HbA1c, FPG and 2hPH were all significantly decreased ( <0.01).Conclusion Insulin pump therapy can imitate the secretion of physiological insulin. It can be used for insulin desensitization.