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目的探讨染色体多态性与生殖异常临床效应的关系。方法对近6年于四川省妇幼保健院门诊就诊的3156例生殖异常患者进行染色体核型及临床分析。结果 3156例生殖异常患者中,检出染色体多态性变异309例,占9.79%。从临床表现看,妊娠胎儿丢失者染色体多态性变异为9.66%;不孕不育者染色体多态性变异为8.99%;胎儿畸形、出生缺陷者染色体多态性变异为13.85%。结论染色体多态性与生殖异常存在一定的关系,不能忽视生殖异常病人的染色体多态性。
Objective To explore the relationship between chromosomal polymorphisms and clinical effects of reproductive abnormalities. Methods Chromosome karyotypes and clinical analysis of 3156 cases of genital abnormalities in outpatient clinics in MCH in Sichuan Province in recent 6 years were performed. Results Among 3156 cases of genital abnormalities, 309 cases were detected polymorphism, accounting for 9.79%. From the clinical manifestations, the genetic variation of chromosome loss in pregnant women was 9.66%; the variation of chromosome polymorphism in infertility was 8.99%; the variation of chromosome polymorphism in fetus with birth defects was 13.85%. Conclusion There is a certain relationship between chromosomal polymorphism and reproductive abnormalities. Chromosome polymorphisms in patients with reproductive abnormalities can not be ignored.