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CA_(125)是一种细胞表面的高分子量粘液样糖蛋白,1981年由Bast首先发现,80％以上的非粘液表皮卵巢癌可表达这种抗原,除卵巢癌以外,CA_(125)与肺癌关系密切,研究表明,CA_(125)具有肺癌标志物的良好特征,是一个很好的判断肺癌预后的指标。本文拟就CA_(125)与肺癌的关系加以概述,探讨CA_(125)作为肺癌标志物的意义。 1 CA_(125)的发现及其来源 1981年Bast等用卵巢浆液性乳头状囊腺癌建立的上皮细胞株OVCA433免疫BALB/C小鼠,三天后取免疫小鼠脾细胞与P_3/NS-1骨髓瘤相融合,经筛选分离后获得一株单克隆细胞命名为OC_(125),该细胞分泌针对卵巢癌抗原的单克隆抗体,这是一种单克隆免疫球蛋白(IgG),由OC_(125)识别的抗原分子为CA_(125)。
CA_(125) is a cell surface high-molecular-weight mucoid-like glycoprotein, first discovered by Bast in 1981, more than 80% of non-mucinous epithelial ovarian cancer can express this antigen, in addition to ovarian cancer, CA_(125) and lung cancer Closely related, studies have shown that CA_(125) has good features of lung cancer markers and is a good indicator of prognosis of lung cancer. This article outlines the relationship between CA125 and lung cancer, and explores the significance of CA125 as a lung cancer marker. 1 The discovery and origin of CA_(125) 1981 Bast et al. immunized BALB/C mice with an epithelial cell line OVCA433 established by ovarian serous cystadenocarcinoma and immunized mice with splenocytes and P_3/NS-1 three days later. After myeloma fusion, a monoclonal cell named OC_(125) was obtained after screening and isolation. The cell secreted a monoclonal antibody against ovarian cancer antigen, which is a monoclonal immunoglobulin (IgG), by OC_ ( 125) The recognized antigen molecule is CA_(125).