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部分贲门癌组织中存在一定比例的内分泌样癌细胞，一般认为其发生是多能干细胞多向分化而来，但对其发生的分子学基础了解甚少。我们采用嗜铬蛋白 A(chromogranin A,CGA)多抗和 p53单抗标记的免疫组化方法，检测贲门癌组织内分泌分化及 p53蛋白表达的变化，并分析两者之间的关
In some cardiac cancer tissues, there is a certain proportion of endocrine-like cancer cells. It is generally believed that the occurrence of pluripotent stem cells is multi-directional differentiation, but little is known about the molecular basis of its occurrence. We used the immunohistochemical method of chromogranin A (CGA) polyclonal antibody and p53 monoclonal antibody to detect endocrine differentiation and p53 protein expression in cardiac cancer tissues and analyze the relationship between them.