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目的探讨抗焦虑抗抑郁药物对焦虑抑郁症合并乙肝患者乙肝病情的影响。方法将我院精神病科2011年4月至2014年4月收治的焦虑症、抑郁症合并乙肝患者作为研究对象,按乙肝病情分为大三阳组和小三阳组。两组根据病情给予相应的抗焦虑、抗抑郁药物治疗,每隔半年使用ELISA方法检测血清中乙肝病毒标记物,采用Excel软件统计结果。结果大三阳组和小三阳组患者血清中乙肝病毒标记物指标均有不同程度的变化,大三阳组变化最明显,5项指标均为阴性的有3例,而小三阳组有1例;但小三阳的转归效果最好,三年的转归率分别为44.44%、66.67%和81.48%;大三阳组的转归率分别为30.77%、53.85%和69.23%。结论积极的精神情绪对焦虑抑郁症合并乙肝患者的病情有一定的干预效果,且对小三阳患者的转归促进作用最佳。
Objective To investigate the effect of anti-anxiety and anti-depressant drugs on hepatitis B in patients with hepatitis B and anxiety and depression. Methods The psychiatric patients in our hospital from April 2011 to April 2014 admitted to the anxiety and depression patients with hepatitis B as the research object, according to the condition of hepatitis B divided into Sansheng group and Xiaosanyang group. The two groups were given corresponding anxiolytic and antidepressant drugs according to the condition. Serum HBV markers were detected every 6 months using Excel software. Results The serum HBV markers of patients in Dasanyang group and Xiaosanyang group all had different degrees of change, the Dasanxang group had the most obvious changes, the three indexes were negative in 3 cases, and the group of Xiaosanyang group had 1 case However, the outcome of Xiaosanyang was the best, with the three-year rates of return being 44.44%, 66.67% and 81.48% respectively; the success rates of Da Sansang were 30.77%, 53.85% and 69.23% respectively. Conclusion The positive mental state has certain intervention effect on the condition of patients with hepatitis A and depression and the best prognosis for the patients with small Sanyang.