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目的探讨多索茶碱治疗慢性阻塞性肺疾病急性加重期的临床疗效。方法选取2013年7月—2015年7月张家界市仁康中医院院收治的110例慢性阻塞性肺疾病急性加重期患者,随机分为对照组与研究组,各55例。两组患者均予以吸氧、抗感染、β2受体激动药剂等常规治疗,在此基础上,对照组予以氨茶碱治疗,研究组予以多索茶碱治疗,比较两组患者临床疗效及不良反应发生情况。结果研究组总有效率高于对照组,差异有统计学意义(P<0.05);治疗后研究组第1秒用力呼气容积(FEV_1)、第1秒用力呼气容积占用力肺活量的百分比(FEV_1/FVC)、动脉血氧饱和度(Sa O_2)、氧分压(PO_2)高于对照组,差异有统计学意义(P<0.05);两组患者不良反应发生率比较,差异有统计学意义(P<0.05)。结论多索茶碱治疗慢性阻塞性肺疾病急性加重期的临床疗效显著,且不良反应少。
Objective To investigate the clinical efficacy of doxofylline in the treatment of acute exacerbation of chronic obstructive pulmonary disease. Methods From July 2013 to July 2015, 110 patients with acute exacerbation of chronic obstructive pulmonary disease admitted to Renkang Hospital of Traditional Chinese Medicine, Zhangjiajie were randomly divided into control group and study group, with 55 cases in each group. Two groups of patients were given oxygen, anti-infection, β2 receptor agonist and other conventional treatment, on this basis, the control group was treated with aminophylline, the study group was treated with doxofylline, the clinical efficacy and adverse reactions of the two groups were compared Reaction occurred. Results The total effective rate of the study group was higher than that of the control group (P <0.05). After the treatment, the forced expiratory volume in one second (FEV_1), forced expiratory volume in one second (FEV_1 / FVC), arterial oxygen saturation (Sa O_2) and oxygen partial pressure (PO_2) were significantly higher than those in the control group (P <0.05). There was a statistically significant difference in adverse reactions between the two groups Significance (P <0.05). Conclusion Doxofylline has a significant clinical effect in the treatment of acute exacerbation of chronic obstructive pulmonary disease with less adverse reactions.