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本文对10例胰岛素抗体(IAb)阳性和11例IAb阴性糖尿病病人在皮下注射正规胰岛素(14U)后作了7(1/2)小时动态观察,研究了IAb与胰岛素降糖作用之间的关系。结果提示:IAb浓度与胰岛素开始作用时间、降5.55mmol/L血糖时间延迟有关。IAb浓度和最大结合能力对胰岛素代谢和糖的利用的影响比胰岛素抗体亲和力更为重要。
In this paper, we observed the relationship between IAb and insulin-hypoglycemic effects in 10 patients with IAb positive and 11 patients with IAb-negative diabetes after subcutaneous injection of regular insulin (14U) for 7 1/2 hours. . The results suggest that the IAb concentration is related to the onset time of insulin and the delay of 5.55mmol / L blood glucose. The effect of IAb concentration and maximal binding on insulin metabolism and carbohydrate utilization is more important than insulin antibody affinity.