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目的 探讨非小细胞肺癌和食管癌黑色素瘤抗原基因（ＭＡＧＥ）的表达及临床意义。方法 应用ＲＴ－ＰＣＲ技术检测４８ 例肺癌、２８ 例食管癌ＭＡＧＥ３ 和ＭＡＧＥ４ 的表达。结果 非小细胞肺癌ＭＡＧＥ３ 和ＭＡＧＥ４ 表达分别为２１／４８（４３．７％ ）、７／４８（１４．６％ ），食管癌ＭＡＧＥ３ 和ＭＡＧＥ４ 表达分别为１２／２８（４２．９％ ）、５／２８（１７．９％ ），ＭＡＧＥ３ 表达多见于Ⅲ期和淋巴转移患者。结论 ＭＡＧＥ３ 在肺癌和食管癌发展和侵袭中起积极作用，并可能用于对肿瘤进一步免疫治疗。
Objective To investigate the expression and clinical significance of melanoma antigen gene (MAGE) in non-small cell lung cancer and esophageal cancer. Methods RT-PCR was used to detect the expression of MAGE3 and MAGE4 in 48 cases of lung cancer and 28 cases of esophageal cancer. Results The expressions of MAGE3 and MAGE4 in non-small cell lung cancer were 21/48(43.7%) and 7/48(14.6%) respectively. The expression of MAGE3 and MAGE4 in esophageal cancer was 12/28(42.9%), 5 respectively. /28 (17.9%), MAGE3 expression more common in patients with stage III and lymph node metastases. Conclusion MAGE3 plays an active role in the development and invasion of lung cancer and esophageal cancer, and may be used for further immunotherapy of tumors.