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为研究新辅助化疗在胃癌综合治疗中的价值,Schuhmacher、Gretschel、Lordick等人进行了一项新辅助化疗联合手术与单纯手术治疗局部进展期近端胃癌及贲门癌(包括Ⅱ、Ⅲ型胃食管结合部癌)的随机对照试验。该项研究中新辅助化疗共2周期,48 d/周期;方案为d1、d15及d29顺铂50 mg/m2静脉滴注超过1 h并水化,续以四氢叶酸500 mg/m2静脉滴注超过
To investigate the value of neoadjuvant chemotherapy in the comprehensive treatment of gastric cancer, Schuhmacher, Gretschel, Lordick et al conducted a neoadjuvant chemotherapy combined with surgery and simple surgery for the treatment of locally advanced proximal gastric cancer and cardiac cancer (including type Ⅱ, Ⅲ gastroesophageal reflux Junctional cancer) randomized controlled trial. Neoadjuvant chemotherapy in this study, a total of two cycles, 48 d / cycle; d1, d15 and d29 cisplatin 50 mg / m2 intravenous infusion more than 1 h and hydration continued with tetrahydrofolate 500 mg / m2 intravenous infusion Note over