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目的 :分析盐酸溴己新3种注射剂型静脉滴注时药物含量的变化。方法 :分别采用粉针、水针和葡萄糖注射液进行静脉滴注时药物含量的变化监测。结果 :粉针和水针、葡萄糖注射液混合振摇10min与振摇1min,药物含量相同,溶解后立即测定与其放置3h后测定,差异无统计学意义(P>0.05)。粉针、水针经输液器输注过程中,药物含量下降。通过分析发现,滴速为每1min60滴其粉针质量分数下降6.1%,水针含量质量分数下降12.6,输液药物含量在输注过程中未出现下降情况。在每分钟30滴,粉针含量质量下降8.9%,水针下降19.6%,输液药物未出现下降。在每分钟15滴,粉针下降15.9%,水针下降20.1%。通过数据分析可以发现当滴速越慢,其药物损失就越多。结论 :提示临床在应用盐酸溴己新之前需要充分考虑到药物含量下降的问题,注意临床用药。
OBJECTIVE: To analyze the changes of drug content in intravenous drip of 3 kinds of bromhexine hydrochloride injection. Methods: The changes of drug content were monitored by intravenous drip with powder injection, water injection and glucose injection respectively. Results: The powder and water needles and glucose injection were mixed and shaken for 10 min and shaken for 1 min, respectively. The drug content was the same, and the difference was not statistically significant (P> 0.05). Powder, water needle infusion through the infusion process, the drug content decreased. The results showed that the drip rate was decreased by 6.1% and the mass fraction of water needle decreased by 12.6% per drop for 60 drops, while the infusion drug content did not decrease during the infusion. At the rate of 30 drops per minute, the quality of the powdery needle decreased by 8.9%, the water needle decreased by 19.6% and the infusion drug did not appear to drop. At 15 drops per minute, the needle drops 15.9% and the water needle drops 20.1%. The data analysis shows that the slower the drip rate, the more the drug is lost. Conclusion: It is suggested that the clinical application of bromhexine hydrochloride need to take full account of the decline of drug content, pay attention to clinical medication.