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OBJECTIVES: The purpose of this study was to evaluate whether multislice compu ted tomography(MSCT) provides a reliable, noninvasive imaging modality for ident ification of patients with degenerative aortic valve stenosis(AS) by quantifying the aortic valve area(AVA) in comparison to the accepted diagnostic standard tr ansthoracic echocardiography(TTE). BACKGROUND: Management of patients with degen erative AS is based on the severity of disease. The severity of AS in clinical p ractice is assessed by TTE and classified as mild, moderate, or severe according to the AVA. METHODS: Forty-six patients were examined with contrast-enhanced, electrocardiogram-gated, 16-row MSCT for the evaluation of the diagnostic acc uracy. In 30 patients, quantification of the AVA with MSCT was compared to TTE u sing the continuity equation with Doppler velocity-time integral for calculatio n of the AVA. RESULTS: Sensitivity of MSCT for the identification of patients wi th degenerative AS was 100%, and the specificity was 93.7%. Thirty of 46 patie nts had AS determined by TTE. Quantification of AVA by MSCT(mean AVA=0.94 cm2) i n patients with AS showed a good correlation to TTE(r=0.89; p< 0.001). Bland-Al tman plot illustrated good intermodality agreement between the two methods(limit s of agreement, 0.20; 0.29). CONCLUSIONS: Multislice computed tomography may pro vide an accurate, noninvasive imaging technique for detection of patients with A S and quantification of AVA.
OBJECTIVES: The purpose of this study was to evaluate whether multislice compu ted tomography (MSCT) provides a reliable, noninvasive imaging modality for ident ification of patients with degenerative aortic valve stenosis (AS) by quantifying the aortic valve area (AVA) in comparison to the accepted diagnostic standard tr anhoracic echocardiography (TTE). BACKGROUND: Management of patients with degen erative AS is based on the severity of disease. The severity of AS in clinical p ractice is assessed by TTE and classified as mild, moderate, or severe according to the AVA. METHODS: Forty-six patients were examined with contrast-enhanced, electrocardiogram-gated, 16-row MSCT for the evaluation of the diagnostic acc uracy. In 30 patients, quantification of the AVA with MSCT was compared to TTE u sing the continuity equation with Doppler velocity-time integral for calculatio n of the AVA. RESULTS: Sensitivity of MSCT for the identification of patients wi th degenerative AS was 100%, and the s Thirty of 46 patie nts had AS determined by TTE. Quantification of AVA by MSCT (mean AVA = 0.94 cm2) in patients with AS showed a good correlation to TTE (r = 0.89; p <0.001). Bland- Al tman plot illustrated good intermodality agreement between the two methods (limit s of agreement, 0.20; 0.29). CONCLUSIONS: Multislice computed tomography may pro vide an accurate, noninvasive imaging technique for detection of patients with AS and quantification of AVA.