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近年来,国外学者采用定量观察循环血中内皮细胞(Circulating Endothelial Cell,CEC)的方法研究了一些疾病或因素对机体的影响。由于这种方法能结合临床病人研究内皮细胞的数量变化和功能变化,故有一定的临床应用价值。本文综合了国外近几年来分离、计数和鉴定CEC的方法,对65例正常人和65例外科患者的CEC的数量进行了对照观察。目前,国内外尚未见到观察外科患者CEC数量变化的文献报道。 实验结果表明:65例正常人的CEC为1.3±0.7/0.9μl,而65例外科患者的CEC为2.0±0.9/0.9μl,后者较前者有非常显著增多(P<0.001)。其原因尚有待进一步探讨。
In recent years, foreign scholars studied the effects of some diseases or factors on the body by quantitatively observing the Circulating Endothelial Cell (CEC). Because this method can be combined with the clinical study of endothelial cell number changes and functional changes, it has some clinical value. In this paper, the methods of foreign CEC separation, counting and identification in recent years are summarized and the number of CEC in 65 normal subjects and 65 surgical patients is compared. At present, there are still no reports of the changes in the number of CECs in surgical patients at home and abroad. The experimental results showed that the CEC of 65 normal subjects was 1.3 ± 0.7 / 0.9μl, while the CEC of 65 surgical patients was 2.0 ± 0.9 / 0.9μl, which was significantly higher than the former (P <0.001). The reason remains to be further explored.