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目的观察行气健脾法联合西药治疗肝硬化合并糖代谢异常的临床效果。方法将92例肝硬化合并糖代谢异常患者随机分为观察组和对照组,每组46例。观察组采用行气健脾法,方选七味白术散加减,联合护肝、抗病毒、胰岛素及对症支持的西药治疗,对照组单用西药治疗,疗程均为3个月。观察治疗前后2组肝功能、血糖水平及肝硬化并发症发生情况。结果治疗后,2组空腹血糖(FBG)、餐后2 h血糖(2 hPG)较治疗前均下降(P<0.05或P<0.01),但2组治疗后数值比较差异无统计学意义(P>0.05)。2组治疗后肝功能各指标较治疗前均有所改善(P<0.05);且观察组改善程度优于对照组(P<0.05)。观察组并发症发生率为56.52%,低于对照组的76.19%(P<0.05)。结论行气健脾法联合西药治疗肝硬化合并糖代谢异常能够显著改善肝功能,减少并发症,但对控制血糖疗效不显著。
Objective To observe the clinical effects of qi qi spleen combined with western medicine in the treatment of liver cirrhosis complicated with abnormal glucose metabolism. Methods A total of 92 patients with liver cirrhosis complicated with abnormal glucose metabolism were randomly divided into observation group and control group, with 46 cases in each group. The observation group was treated with qi and invigorating the spleen method, prescription of Qiweibaizhu Powder and subtraction, combined with liver protection, antivirus, insulin and symptomatic western medicine treatment. The control group was treated with western medicine only for 3 months. Observed before and after treatment 2 groups of liver function, blood glucose levels and complications of liver cirrhosis. Results After treatment, the fasting blood glucose (FBG) and 2-hour postprandial blood glucose (2 hPG) in both groups were significantly lower than those before treatment (P <0.05 or P <0.01), but there was no significant difference between the two groups > 0.05). The indexes of liver function were improved in both groups after treatment (P <0.05), and the improvement in the observation group was better than that in the control group (P <0.05). The incidence of complications in the observation group was 56.52%, which was lower than 76.19% in the control group (P <0.05). Conclusion qi qi spleen combined with Western medicine treatment of liver cirrhosis with abnormal glucose metabolism can significantly improve liver function and reduce complications, but the effect is not significant for the control of blood glucose.