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目的观察中心性浆液性脉络膜视网膜病变(CSC)和阻塞性睡眠呼吸暂停综合征(OSAS)的关系以及CSC患者和正常人OSAS症状出现的频率。方法收集由眼底血管造影(FFA)和光学相干断层扫描(OCT)确诊的急、慢性CSC患者或其后视网膜色素上皮细胞(RPE)损害患者53例,排除有激素使用史和合并有其他眼底疾病患者18例,确定CSC组35例为病例组,选择无眼底疾病的白内障患者35例作为对照组,两组患者根据年龄、性别和BMI配对。用柏林调查问卷评估OSAS的风险性,处于柏林调查问卷高风险(OSAS+)的患者进一步行PSG确诊OSAS,比较两组间OSAS+的比率和OSAS的患病率。结果病例组和对照组的年龄、性别、BMI、既往疾病史无明显差异。病例组19例(54.3%)OSAS+,而对照组10例(28.6%)OSAS+,病例组7例(20.0%)、对照组1例(2.9%)经PSG确诊为OSAS。结论与对照组比较,CSC患者OSAS的患病风险和患病率均高于一般人群。
Objective To observe the relationship between central serous chorioretinopathy (CSC) and obstructive sleep apnea syndrome (OSAS) and the frequency of OSAS symptoms in both CSC and normal subjects. Methods Fifty-three patients with acute or chronic CSC confirmed by fundus angiography (FFA) and optical coherence tomography (OCT) or their subsequent retinal pigment epithelium (RPE) lesions were excluded from the study. Hormone use history and other retinal diseases were excluded Among the 18 patients, 35 patients in the CSC group were selected as the case group, and 35 patients with cataract without retinal diseases were selected as the control group. The two groups were matched according to age, sex and BMI. Assessing the risk of OSAS using the Berlin questionnaire, patients in the high-risk Berlin survey (OSAS +) underwent PSG-confirmed OSAS further and compared OSAS + prevalence and prevalence of OSAS between the two groups. Results There was no significant difference in age, sex, BMI, past disease history between case group and control group. OSAS + was found in 19 cases (54.3%) in the case group and OSAS + in 10 cases (28.6%) in the control group, 7 cases (20.0%) in the case group and 1 case (2.9%) in the control group. Conclusion Compared with the control group, the prevalence and prevalence of OSAS in CSC patients were higher than those in the general population.