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目的 :探讨IL - 1 β和IL - 8在分泌性中耳炎发生和转归中的作用。 方法 :应用酶联免疫吸附法(ELISA)检测 38例分泌性中耳炎患者 40耳中耳积液中IL - 1 β和IL - 8的含量。 结果 :IL - 1 β和IL - 8在分泌性中耳炎中耳积液中的表达率分别为 80 %和 92 .5% ,早期积液中IL - 1 β和IL - 8的含量高于晚期 (P均<0 .0 0 1 ) ,浆液性积液中二者的含量亦较高 (P <0 .0 0 2 ,P <0 .0 5) ,IL - 8与IL - 1 β的含量呈正相关 (r=0 .83,р <0 .0 1 )。结论 :IL - 1 β和IL - 8是分泌性中耳炎中耳积液形成众多细胞因子中的两种 ,均存在于早期中耳积液中 ,并促进浆液性中耳积液的产生 ,前者对后者的产生有促进作用。
Objective: To investigate the role of IL - 1β and IL - 8 in the pathogenesis and outcome of secretory otitis media. Methods: The levels of IL - 1β and IL - 8 in 40 ears of middle ear were measured by enzyme - linked immunosorbent assay (ELISA). Results: The positive rates of IL - 1β and IL - 8 in middle ear effusion of secretory otitis media were 80% and 92.5%, respectively. The levels of IL - 1β and IL - 8 in early effusion were higher than those in advanced stage P <0.05), and the contents of IL - 8 and IL - 1β were also higher in serous fluid (P <0.01, P <0.05) Correlation (r = 0.83, р <0 .0 1). Conclusion: IL - 1β and IL - 8 are two types of cytokines in the formation of middle ear effusion of secretory otitis media. Both of them are present in the early middle ear effusion and promote the production of serous effusion. The latter has a role in promoting.