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目的:评价n 18F-FDG PET-CT最大标准摄取值(SUVn max)在弥漫大B细胞淋巴瘤(DLBCL)患者预后评估中的价值。n 方法:回顾性分析2002年1月至2018年12月山西省肿瘤医院诊断为DLBCL且治疗前接受n 18F-FDG PET-CT检查的86例患者的临床资料和随访信息。通过受试者工作特征(ROC)曲线选取SUVn max最佳界值(10),将患者分为高SUVn max(≥10)组和低SUVn max(<10)组。采用Kaplan-Meier生存曲线分析SUVn max与总生存(OS)和无进展生存(PFS)时间之间的关系。通过单因素分析和多因素Cox比例风险模型评估SUVn max对DLBCL预后评估的意义。n 结果:86例DLBCL患者中位OS时间53.3个月,3年OS率57.0%,3年PFS率53.5%。高SUVn max组3年OS率44.4%,3年PFS率42.2%;低SUVn max组3年OS率70.7%,3年PFS率65.9%,差异均具有统计学意义(均n P<0.05)。单因素和多因素分析显示,SUVn max是影响DLBCL患者OS和PFS的独立预后因素(OS:n HR=0.454,95%n CI 0.251~0.823,n P=0.009;PFS:n HR=0.521,95% n CI 0.292~0.930,n P=0.027)。n 结论:PET-CT SUVn max与DLBCL患者OS和PFS相关,可以预测DLBCL患者的预后。n “,”Objective:To evaluate the prognostic value of n 18F-FDG PET-CT maximum standardized uptake value (SUVn max) in patients with diffuse large B-cell lymphoma (DLBCL).n Methods:The clinical data and follow-up information of 86 DLBCL patients who were diagnosed and received n 18F-FDG PET-CT before treatment in Shanxi Provincial Cancer Hospital from January 2002 to December 2018 were analyzed retrospectively. The receiver operating characteristic (ROC) curve was used to select the best cut-off value of SUVn max (10), and the patients were divided into high SUVn max (≥10) group and low SUVn max (<10) group. Kaplan-Meier survival curve was used to analyze the relationship of SUVn max with overall survival (OS) time and progression-free survival (PFS) time. The prognostic significance of SUVn max in patients with DLBCL was evaluated by univariate analysis and multivariate Cox proportional hazard model.n Results:The median OS time of 86 patients with DLBCL was 53.3 months, the 3-year OS rate was 57.0%, and the 3-year PFS rate was 53.5%. The 3-year OS rate in the high SUVn max group was 44.4%, and the 3-year PFS rate was 42.2%; the 3-year OS rate in the low SUVn max group was 70.7%, and the 3-year PFS rate was 65.9%; the differences were statistically significant (both n P < 0.05). Univariate and multivariate analyses showed that SUV n max was an independent prognostic factor for OS and PFS in patients with DLBCL (OS: n HR = 0.454, 95% n CI 0.251-0.823, n P = 0.009; PFS: n HR = 0.521, 95% n CI 0.292-0.930, n P = 0.027).n Conclusion:18F-FDG PET-CT SUVn max is associated with OS and PFS, and it can predict the prognosis of patients with DLBCL.n