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用乙型肝炎血源疫苗,按0、1、6程序,分5种不同剂量免疫HBsAg和HBeAg均阳性(双阳性)母亲和仅HBsAg阳性母亲的新生儿,井于首针后8～12个月采血,用放射免疫(RIA)法检测他们的HBsAg和抗-HBs、抗-HBc,以比较不同剂量乙肝疫苗阻断母婴传播的效果。结果,10μg×3组对双阳性和仅HBsAg阳性母亲的新生儿的保护率,分别是42.9％和53.5％;20μ×3组为67.4％和69.7％;30μg、10μg、10μg组为75.6％和79.8％,30.20、20μg(含30、30、10μg)组为80.2％和81.5％;30μg×3组为82.3％和83.7％。随疫苗剂量增加保护率逐渐增加,抗-HBs阳转率也是如此。
Hepatitis B vaccine was used to immunize HBsAg and HBeAg positive (double positive) mothers and HBsAg positive mothers only in 5 different doses according to 0, 1, 6 procedures. After the first needle, 8 to 12 Blood samples were taken from January to December of 2004. Their HBsAg, anti-HBs and anti-HBc were detected by radioimmunoassay (RIA) to compare the effects of different doses of hepatitis B vaccine on the mother-to-child transmission. As a result, the protective rates of 10 μg × 3 groups to neonates with double-positive and HBsAg-positive mothers were 42.9% and 53.5% respectively, 67.4% and 69.7% in 20 μ × 3 groups, 75.6% in 30 μg, 10 μg and 10 μg groups, and 79.8%, 30.20, 20μg (including 30, 30, 10μg) group were 80.2% and 81.5%, respectively, and those in 30μg × 3 group were 82.3% and 83.7%. As the dose of vaccine increases, the protection rate gradually increases, as is the anti-HBs positive rate.