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目的:优化鞣花酸壳聚糖-海藻酸钠微球的最佳制备工艺。方法:采用一步法,以壳聚糖-海藻酸钠作为载体材料制备鞣花酸微球,并以微球载药量和包封率为考察指标,通过单因素筛选及正交设计优化出鞣花酸壳聚糖-海藻酸钠微球的制备工艺。用溶出仪在900 ml释放介质(pH6.86)和120 r·min-1转速条件下测定释放度。结果:优化工艺为海藻酸钠与药物比为3∶1,氯化钙质量分数为2%,海藻酸钠质量分数为2%,壳聚糖质量分数为0.1%,温度为60℃,pH为5,所得鞣花酸平均粒径为(980±100)μm,平均载药量为27.22%,平均包封率为97.73%,48 h释放度为74.22%。结论:本制备工艺稳定,操作简便,重现性好,可用于鞣花酸壳聚糖-海藻酸钠微球的制备。
Objective: To optimize the preparation of ellagic acid chitosan - alginate microspheres. Methods: The ellagic acid microspheres were prepared by one-step method using chitosan-sodium alginate as carrier material. The drug loading and entrapment efficiency of the microspheres were taken as the index to evaluate the tannin microspheres. Single-factor screening and orthogonal design were used to optimize the tannin Preparation of Flower Acid Chitosan - Sodium Alginate Microspheres. The dissolution was measured with a dissolution apparatus under the conditions of 900 ml release medium (pH6.86) and 120 r · min-1 rotation speed. Results: The optimum conditions were as follows: sodium alginate to drug ratio 3:1, calcium chloride 2%, sodium alginate 2%, chitosan 0.1%, temperature 60 ℃, pH The average particle size of ellagic acid was (980 ± 100) μm, the average drug loading was 27.22%, the average entrapment efficiency was 97.73%, and the release rate was 74.22% after 48 h. Conclusion: The preparation process is stable, easy to operate, reproducible, and can be used for the preparation of ellagic acid chitosan-alginate microspheres.