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AIM: To investigate the association between peroxisome proliferator-activated receptor-γ (PPAR-γ ) gene polymorphism 34 C>G and colorectal cancer (CRC),a meta-analysis review was performed in this report.METHODS: A systematic literature search and selection of eligible relevant studies were carried out.Nine independent studies with a total number of 4533 cases and 6483 controls were included in the meta-analysis on the association between polymorphism 34 C>G and CRC.RESULTS: There was no evidence for the association between PPAR-γ 34 C>G and CRC if all of the subjects in the nine studies were included.However,CG + GG showed a marginally significant difference from CC (OR = 0.84,95% CI: 0.69-1.01,P = 0.07) in random-effect model.Stratified meta-analysis indicated that PPAR-γ 34 C>G was associated with colon cancer (OR = 0.8,95% CI: 0.65-0.99,P = 0.04) in random-effect model,and the G allele decreased colon cancer risk.No significant association was observed between PPAR-γ 34 C>G and rectal cancer.CONCLUSION: PPAR-γ 34 C>G is associated with colon cancer risk,but not associated with CRC and rectal cancer risk.
A investigate the association between peroxisome proliferator-activated receptor-γ (PPAR-γ) gene polymorphism 34 C> G and colorectal cancer (CRC), a meta-analysis review performed in this report. METHODS: A systematic literature search and selection of eligible relevant studies were carried out. Neine independent studies with a total number of 4533 cases and 6483 controls were included in the meta-analysis on the association between polymorphism 34 C> G and CRC.RESULTS: There was no evidence for the association Between PPAR-γ 34 C> G and CRC if all of the subjects in the nine studies were included. However, CG + GG showed a marginally significant difference from CC (OR = 0.84, 95% CI: 0.69-1.01, P = 0.07 ) in random-effect model. Stratified meta-analysis indicated that PPAR-γ 34 C> G was associated with colon cancer (OR = 0.8,95% CI: 0.65-0.99, P = 0.04) G allele decreased colon cancer risk. No significant association was observed between PPAR-γ 34 C> G an d rectal cancer. CONCLUSION: PPAR-γ 34 C> G is associated with colon cancer risk, but not associated with CRC and rectal cancer risk.