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作者对72(男42、女30)例多发性硬化(MS)进行了临床电生理、免疫学和生物化学等的动态观察。其中45例呈典型缓解病程,19例呈进行性病程,8例在5年内病情稳定。最常见的症状为颅神经损害(84％)、运动-反射障碍(86％)和共济运动障碍(72％)。一、脑电图(EEG):共检查109例次。有81.5％呈弥漫性改变(其中19.2％为轻度,34％为中度),常见于病情恶化和有脑干症状的患者;28.4％为重度弥漫性改变,多见于疾病呈进行性过程和病变以小脑为主者。生物电活动障碍的程度与临床症状的严重性无明显的平行关系,但与病程有关。二、肌电图(EMG):31％在恶化期(以锥体系损害为主)表现为肌肉随意收缩时波幅下降,而在缓解期波幅明显增高,但始终低于正常。6％脊髓型患者
The authors of 72 (42 men and 30 women) cases of multiple sclerosis (MS) were performed electrophysiology, immunology and biochemistry and other dynamic observation. Among them, 45 cases showed a typical disease course, 19 cases had a progressive disease course, and 8 cases were stable in 5 years. The most common symptoms were cranial nerve damage (84%), motor-reflexes (86%) and ataxia (72%). First, the electroencephalogram (EEG): A total of 109 cases examined. 81.5% showed diffuse changes (of which 19.2% were mild and 34% were moderate), which were common in patients with exacerbations and symptoms of brainstem; 28.4% were severe diffuse changes, more common in the progressive disease process and Lesions to the cerebellum-based. The degree of bioelectrical activity disorder and the severity of clinical symptoms no significant parallel, but with the course. Second, electromyography (EMG): 31% in the deterioration of the cone system (mainly damage to the cone) showed muscle contraction amplitude decreased at random, while the amplitude was significantly higher in remission, but always lower than normal. 6% spinal cord patients