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当从已知化学成份的饲料中去掉吡咯并喹啉苯醌(PQQ)后,可观察到小鼠生长缓慢、不能繁殖,并出现骨质山黧豆中毒类似症状,严重者则出现皮肤易裂、皮肤胶原蛋白很易在中性盐溶液中被提取以及赖氨酰氧化酶水平下降。已证明结缔组织的功能缺陷以及生长迟缓与PQQ的缺乏有关。这表明PQQ主要起着生长因子及维生素的作用。
When pyrroloquinoline quinone (PQQ) was removed from feedstuffs of known chemical composition, mice were observed to grow slowly, unable to multiply, and developed similar symptoms of osteoporosis, while in severe cases, the skin became fissile , Skin collagen is easily extracted in neutral salt solution and the lysyl oxidase level is decreased. Defects in connective tissue and growth retardation have been shown to be associated with a lack of PQQ. This shows that PQQ plays a major role in growth factors and vitamins.