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目的:探索利拉鲁肽联合二甲双胍治疗对Ⅱ型糖尿病患者血糖及生活质量的影响。方法:回顾性分析2014年2月-2015年2月本院诊治的100例Ⅱ型糖尿病患者临床资料,按照不同治疗方式分为两组(各50例),对照组予二甲双胍单药治疗,研究组予利拉鲁肽联合二甲双胍治疗,对比两组临床疗效、生活质量评分及不良事件。结果:两组治疗后血糖指标(FBG、2hPG、HbAlc)水平均显著低于治疗前,且IR显著提高,但是研究组改善幅度更大,优于对照组(P<0.05,P<0.01);两组治疗后生活质量各指标评分均显著高于治疗前,其中研究组提高幅度更大(P<0.05,P<0.01)。结论:利拉鲁肽联合二甲双胍治疗对Ⅱ型糖尿病患者效果显著,可有效降低血糖指标水平,提高胰岛素敏感度,改善患者生活质量,对身体无不良影响,具临床实际应用价值。
Objective: To explore the effects of liraglutide plus metformin on blood glucose and quality of life in type 2 diabetic patients. Methods: The clinical data of 100 type Ⅱ diabetic patients diagnosed and treated in our hospital from February 2014 to February 2015 were retrospectively analyzed. The patients were divided into two groups (50 cases each) according to different treatment methods. The control group was treated with metformin monotherapy. The patients were treated with liraglutide and metformin, and the clinical efficacy, quality of life and adverse events were compared between the two groups. Results: After treatment, the levels of FBG, 2hPG and HbAlc in both groups were significantly lower than those before treatment, and the levels of IR increased significantly. However, the improvement in the study group was greater than that in the control group (P <0.05, P <0.01). The scores of quality of life after treatment in both groups were significantly higher than before treatment, in which the research group increased more significantly (P <0.05, P <0.01). Conclusion: The combination therapy of liraglutide and metformin has significant effect on patients with type Ⅱ diabetes mellitus, which can effectively lower the level of blood glucose, improve insulin sensitivity and improve the quality of life of patients with no adverse effect on the body, which has clinical value.