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We study initial boundary value (IBV) problem for a class of generalized Navier-Stokes equations in Lq([0, T); LP(Ω)). Our main tools are regularity of analytic semigroup by Stokes operator and space-time estimates. As an application we can obtain some classical results of the Navier-Stokes equations such as global classical solution of 2-dimensional Navier-Stokes equation etc.