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目的:观察二磷酸钠果糖治疗新生儿缺氧缺血性脑病的疗效。方法:对76例HIE患儿随机分为两组,观察组38例用二磷酸钠果糖治疗,对照组38例用胞二磷胆碱治疗,治疗一个疗程后根据患儿面色、呼吸、哭声、心率、肌张力等判定疗效。结果:观察组总有效率81.6%,明显优于对照组71.1%(P<0.05)。另外新生儿神经行为评分(NBNA),两组重度异常率也有明显差异,观察组明显优于对照组(P<0.05)。结论:二磷酸钠果糖治疗新生儿缺血缺氧性脑病在总有效率、临床神经症状体征恢复时间NBNA评分等方面均比胞二磷胆碱组疗效好,未见明显不良反应。
Objective: To observe the effect of sodium diphosphate fructose on neonatal hypoxic-ischemic encephalopathy. Methods: Totally 76 children with HIE were randomly divided into two groups. 38 cases in the observation group were treated with sodium diphosphate fructose and 38 cases in the control group were treated with citicoline. After a course of treatment, , Heart rate, muscle tension, etc. to determine the efficacy. Results: The total effective rate was 81.6% in the observation group, which was significantly better than 71.1% in the control group (P <0.05). In addition, neonatal neurobehavioral score (NBNA), two groups of severe abnormalities also have significant differences, the observation group was significantly better than the control group (P <0.05). CONCLUSION: Sodium diphosphate fructose treatment of neonatal hypoxic-ischemic encephalopathy in the total effective rate, clinical neurological symptoms and signs of recovery time NBNA score were better than the citicoline group, no significant adverse reactions.