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目的:总结1例血友病性关节炎合并丙肝患者同期行单侧髋、膝关节置换术患者的围手术期护理经验。方法:2018年8月，兰州大学第一医院收治1例血友病性关节炎合并丙肝患者,对患者做好健康宣教、功能锻炼、检查评估等术前准备，同期行单侧髋、膝关节置换术。术后加强切口及导管管理，积极预防并发症，在做好疼痛管理及安全的凝血因子活性条件下指导患者进行功能康复锻炼；整个围手术期注重凝血因子替代治疗的护理。结果:经过精心护理，患者住院期间未发生严重并发症，出院前影像学检查假体位置及力线满意。结论:通过本例患者围手术期护理证明，上述护理措施对同期行单侧髋、膝关节置换术的血友病性关节炎合并丙肝患者是有效的。“,”Objective:To summarize the perioperative nursing experience of a patient with hemophilia arthritis complicated with hepatitis C undergoing unilateral hip and knee arthroplasty at the same time.Methods:In August 2018, a patient with hemophilic arthritis complicated with hepatitis C was admitted to the first hospital of Lanzhou University. Preparations for health education, functional exercises, examination and evaluation before operation was made. Unilateral hip and knee arthroplasty were performed at the same time, strengthen the management of incisions and catheters after the operation, actively prevent complications, and guide patients to perform functional rehabilitation exercises under the conditions of good pain management and safe coagulation factor activity; pay attention to the nursing of coagulation factor replacement treatment in the whole perioperative period.Results:After careful nursing, no serious complications occurred during the patient's hospitalization, and the position and force line of the prosthesis were satisfactory by imaging examination before discharge.Conclusion:The perioperative care of this patient proved that the above-mentioned nursing measures are effective for hemophilic arthritis patients with hepatitis C undergoing unilateral hip and knee arthroplasty at the same time.