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目的观察阿魏酸钠与氯沙坦联用治疗2型糖尿病早期肾病的临床疗效。方法回顾性分析86例2型糖尿病早期肾病患者的临床资料,将其平均分成对照组和观察组。两组均给予氯沙坦治疗,观察组加用阿魏酸钠注射液。比较两组的临床疗效。结果两组病例的UAER、Scr、BUN、FBG均较治疗前均明显降低(P<0.05),有统计学意义。其中,治疗组的UAER明显好于对照组(P<0.05),有统计学分析意义。治疗过程中均无严重不良反应发生。结论阿魏酸钠注射液与氯沙坦联用治疗2型糖尿病早期肾病的效果较好,值得在临床中推广使用。
Objective To observe the clinical efficacy of sodium ferulate combined with losartan in the treatment of type 2 diabetic nephropathy. Methods The clinical data of 86 patients with early stage nephropathy of type 2 diabetes mellitus were retrospectively analyzed. They were equally divided into control group and observation group. Both groups were given losartan treatment, the observation group plus sodium ferulate injection. The clinical efficacy of the two groups was compared. Results The UAER, Scr, BUN and FBG in both groups were significantly lower than those before treatment (P <0.05), which were statistically significant. Among them, the treatment group UAER was significantly better than the control group (P <0.05), statistically significant. No serious adverse reactions occurred during the treatment. Conclusion Sodium ferulate injection combined with losartan in the treatment of early type 2 diabetic patients with early nephropathy better, it is worth promoting in the clinic.