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目的探讨丙氨酰谷氨酰胺对脓毒症患者免疫状态的影响。方法选取符合入选标准的进入ICU的脓毒症患者42例,均随机分为对照组和治疗组。对照组给予标准治疗,治疗组则在此基础上给予丙氨酰谷氨酰胺,以免疫调理观察疗效。比较两组抗生素使用时间、住ICU时间、治疗7d后PCT、WBC变化。结果脓毒症治疗组抗生素使用时间、住ICU时间明显缩短,7d后PCT、WBC较对照组明显下降(P<0.05)。结论丙氨酰谷氨酰胺可以改善肠道黏膜屏障功能,调节免疫,提高免疫力,在一定程度上可以改善预后。
Objective To investigate the effect of alanyl glutamine on the immune status in sepsis patients. Methods Forty-two patients with sepsis admitted to the ICU who met the inclusion criteria were randomly divided into control group and treatment group. Control group given standard treatment, the treatment group is given on this basis alanyl glutamine to observe the effect of immunomodulation. The antibiotic use time, ICU time and the change of PCT and WBC after 7 days of treatment were compared between the two groups. Results The antibiotic use time and ICU time in sepsis treatment group were significantly shortened, and PCT and WBC decreased significantly after 7 days (P <0.05). Conclusion Alanyl glutamine can improve intestinal mucosal barrier function, regulate immunity and improve immunity, to a certain extent, improve prognosis.