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要了解受体调整尤其“下调”对充血性心力衰竭(CHF)的意义,须知心血管系统反应是通过受体兴奋所介导的.β受体激动剂例如多巴胺、多巴酚丁胺和异丙肾上腺素等,对CHF有正性肌力作用.心肌β受体短期兴奋,使心肌收缩力和收缩频率增加.在正常心脏,这种收缩力增加使腺苷酸环化酶激活,细胞内环腺苷酸(cAMP)随之增加;但CHF时,β受体持久兴奋不足以维持正性肌力作用.慢性CHF(心功能Ⅲ～Ⅳ级)病人用多巴酚丁胺和吡布特罗(Pirbuterol)治疗时,
To understand the significance of receptor modulation, especially “down regulation,” in patients with congestive heart failure (CHF), it is important to note that cardiovascular responses are mediated through receptor agonists.β-receptor agonists such as dopamine, dobutamine And isoproterenol, etc., a positive inotropic effect on CHF. Myocardial β receptor short-term excitement, myocardial contractility and contraction frequency increased in normal heart, this increase in contractile activation of adenylate cyclase, Intracellular cyclic adenosine monophosphate (cAMP) increased; but CHF, β receptor long-lasting excitement is not enough to maintain the positive inotropic effect of chronic CHF (cardiac function Ⅲ ~ Ⅳ grade) patients with dobutamine and pyridine When treated with Pirbuterol,