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目的探讨珠海地区妇女宫颈上皮内瘤变与高危型人乳头瘤病毒亚型的关系。方法采用杂交捕获二代(HC-Ⅱ)方法定量检测珠海地区宫颈疾病患者HPV-DNA的含量,全部269例患者阴道镜下多点取活组织病理检查,根据病理学诊断结果分组。结果珠海地区高危型HPV在慢性宫颈炎、C INⅠ、C INⅡ及C INⅢ的感染率分别为13.5%、48.2%、73.8%及93.7%,HPV16在四组中感染率依次为3.6%、13.4%、47.6%及65.6%,宫颈病变存在多重HPV感染。结论珠海地区宫颈上皮内瘤变患者感染HPV16、18、31、58及35型较多见,多重HPV感染可能促进宫颈上皮内瘤变的发生。
Objective To investigate the relationship between cervical intraepithelial neoplasia and high-risk human papillomavirus subtype in Zhuhai area. Methods The hybridization capture second generation (HC-Ⅱ) method was used to quantitatively detect HPV-DNA in patients with cervical diseases in Zhuhai. All 269 patients underwent pathological examination by colposcopy and histopathological diagnosis. Results The infection rates of HPV IN CINⅠ, C INⅡ and CINⅢ were 13.5%, 48.2%, 73.8% and 93.7% respectively in Zhuhai area. The infection rates of HPV16 in the four groups were 3.6%, 13.4% , 47.6% and 65.6% respectively. There were multiple HPV infections in cervical lesions. Conclusions In patients with cervical intraepithelial neoplasia in Zhuhai, HPV16, HPV18, HPV18, HPV18 and HPV35 are more common, and multiple HPV infection may promote cervical intraepithelial neoplasia.